There are cases where reposts on some Mastodon instances and most of Misskey’s reposts aren’t seen on Firefish, but are seen on Misskey, because for some reason Misskey seems to have better protocol interoperability, so you get a vastly different experience even when following the same people.

Some cheese is nice, some is cool, some is disgusting, some is straight-up inedible to me.

Also, Boosts in Kbin are more effective than upvotes but it’s not obvious to a person who isn’t aware of that

The same problem I have when it comes to Mastodon/Misskey/Firefish - I feel like everything is so fragmented, like I have to jump from one place to another. Thankfully, this applies significantly less in the “threadiverse” (Outdated name, we definitely need a new one) because there aren’t 6 different platforms and tens of different forks, and Lemmy and Kbin are pretty much 100% compatible with one another, unlike those moments where you can’t see Mastodon re-toots on Firefish a lot of the time or sometimes accounts’ posts appear much later in a different instance. We don’t need to worry about that here.

PrivacyTests makes it look like Brave is the only browser you should be using simply based on how good it is at blocking trackers by default. Brave is good, but it has it’s fair share of flaws from UI and terrible syncing to built in crypto and NFT stuff.

This page has some good recommendations. I suggest you to do research about each solution before picking one that fits your needs.