The problem with scraping is that while it’s difficult/impossible to block completely, it’s pretty easy to keep making changes to your site to disrupt scrapers. The work required by the scraper to adapt to those changes is usually way more than the work you put in to disrupt them.
So if a commercial site wants to make scraping unreliable and impractical, they almost certainly can.
It’s not easily block able as it scrapes the YouTube website. They’d have to stop having a website for that to happen.
The problem with scraping is that while it’s difficult/impossible to block completely, it’s pretty easy to keep making changes to your site to disrupt scrapers. The work required by the scraper to adapt to those changes is usually way more than the work you put in to disrupt them.
So if a commercial site wants to make scraping unreliable and impractical, they almost certainly can.
It’s also easy for the NewPipe devs to update their app and make it work again. This has been going on for years already.